Some people get depressed when they find out how huge the universe is. They feel tiny and insignificant and think that nothing matters in this world.
That makes no more sense than getting depressed when you find out that cows are bigger than you. What is the big deal about bigness? A cow is much bigger than you, but it is a ridiculous animal and you are a valuable person. You know it’s a cow. It doesn’t know anything. it just stands there eating grass (grass!) and mooing. And if it were bigger, that would only make it more ridiculous.
I think that is a complete refutation of the idea that the size of the universe makes us insignificant, or is depressing any other way.